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If OI are more opioid-tolerant than NIO, we hypothesize they would: (1) under controlled conditions, exhibit attenuated responses to a standard opioid challenge, as found in a preliminary study [46], (2) in an outpatient setting, use higher doses of illicit opioids to overcome this tolerance, (3) require higher buprenorphine concentrations to deter illicit opioid use, and (4) tolerate such higher buprenorphine concentrations without a clinically significant increase in safety problems (i.e., larger therapeutic window)

906 Because Medicaid pays for nursing home and other longterm care services, the high use of these services by people with dementia translates into high costs to Medicaid

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This matters for peptide selection because different peptides target different aspects of this metabolic disruption

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