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The matrix physically blocks drug penetration, and bacteria inside biofilms alter their metabolic state in ways that make standard antibiotics far less effective

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N Z Med J 127:816 Wang H, Li L, Qin LL, Song Y, Vidal-Alaball J, Liu TH (2018) Oral vitamin B12 versus intramuscular vitamin B12 for vitamin B12 deficiency

NNMT pathway research, NAD metabolism models, metabolic signaling studies

Instead, the most common cause of such deficiency is pernicious anaemia