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Ferroptosis is defined by excessive intracellular iron accumulation due to metabolic imbalance, where Fe 2+ generates a large amount of hydroxyl radicals (OH) through the Fenton reaction (Figure 2)

Inconsistency was calculated using an I 2 statistic to determine the impact of heterogeneity

Pyruvate dehydrogenase deficiency is a metabolic disorder caused by mutations in the PDHA1 gene or other genes related to the pyruvate dehydrogenase complex

Olmos S

Recent studies have shown that FSP1 effectively prevents ferroptosis caused by GPX4 deletion or inhibition, and its expression increases when GPX4 expression is reduced

Tissue hypoxia is a central feature of sepsis