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Among the earliest and strongest changes in leaves during developmental senescence are chloroplast breakdown (Masclaux, 2000
Induced by probiotics in kefir, including Lactobacillus and Bifidobacteria, gut microbes contributed to the release of insulinotropic polypeptides and glucagon-like peptide-l that boost the glucose uptake of muscle [73], thus reducing blood glucose

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Furthermore, the translation of findings from in vitro and animal studies to human physiology presents another significant challenge

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