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Numerous in vitro studies show that ITCs induce apoptosis via both intrinsic and extrinsic pathways (108)for instance, through caspase activation (109), mitochondrial dysfunction (110), and oxidative stress generation (111)

Berndt, C., Schwenn, J

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Under some pathological conditions, decreased GSH levels could have critical influences on neuronal activities, leading to neurodegeneration

Furthermore, shiitake mushrooms are recognized as one of the top sources of ergosterol, a precursor to vitamin D 2 in the human body [5]