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& Chirila, E

J Int Med Res 41:9931001

About the Ontario Health Technology Assessment Series To conduct its comprehensive analyses, Evidence Development and Standards and its research partners review the available scientific literature, making every effort to consider all relevant national and international research

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For example, overexpression of ATP-binding cassette (ABC) transporters, including ABCB1 (P-glycoprotein) and ABCC1 (multidrug resistance-associated protein), increases the release of 5-FU from malignant cells, reducing its intracellular concentration and effectiveness (Rahmanian et al., 2021)