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The mechanistic data summarized here derive largely from in vitro cell-culture systems and rodent models

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[DOI] [PubMed] [Google Scholar] 62.Madanchi M., Fagagnini S., Fournier N., Biedermann L., Zeitz J., Battegay E., Zimmerli L., Vavricka S.R., Rogler G., Scharl M

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Starting both agents at lower doses than typically used for monotherapy and escalating more slowly can improve tolerability