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171 WuX.WanM.LiG.XuZ.ChenC.LiuF.et al (2006)

This ongoing demand means glutathione levels are constantly under strain, making effective supplementation key to maintaining optimal health

Current limitations include the lack of early-phase clinical trials and safety concerns in cirrhotic livers, the lack of specificity and systemic toxicity of available NRF2 inhibitors, the genetic and molecular heterogeneity in HCC tumors, and the absence of validated biomarkers for NRF2 activity and therapeutic response

[DOI] [PMC free article] [PubMed] [Google Scholar] 367.Kolibab K, Smithson SL, Rabquer B, Khuder S, Westerink MA

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