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Description
Environmental Factors: Pollution: Exposure to environmental pollutants and toxins can damage the skin and contribute to pigmentation problems

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Steinberger RE, Holden PA
The skin brightening happens because glutathione can slow down melanin production, which is what gives your skin its color

and elevated 4-HNE levels found in both cartilage and synovial fluid of surgically induced canine OA models, where direct intra-articular injection of 4-HNE could replicate the cartilage destruction phenotype, accompanied by significant upregulation of MMP13, ADAMTS5, and cyclooxygenase-2 (COX2) expression (Shi et al., 2014)

Chang, A
