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Description
10.1126/scisignal.aao6604 57

BCL-2 family proteins control cell death or differentiation primarily through the irreversible release of intermembrane space proteins, caspase activation, and apoptosis through direct interaction-regulated mitochondrial outer membrane permeabilization (MOMP)

2018 Aug 16 PMID: 30116867 Vaccaro, A.R., Beutler, W., Peppelman, W., Marzluff, J., Mugglin, A., Ramakrishnan, P.S., Meyer, J., Baker, K.J.: Clinical Trial Randomized, Controlled Investigational Device Exemption Disease: Results from Seven-Year Follow-Up of a Prospective, SECURE-C Cervical Artificial Disc for 1-Level Cervical Disc Long-Term Clinical Experience with Selectively Constrained

Buffer conditions were as follows: Binding buffer: 50 mM NaH 2 PO 4 , 150 mM NaCl and 10 mM Imidazole, pH 7.4 Elution buffer: 50 mM NaH 2 PO 4 , 150 mM NaCl and 100 mM imidazole, pH 7.4 On purification, the protein co-elutes with chaperones and non-specific bands

However, LDHA under hypoxia can generate L-2-HG
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