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Serious side effects include weakened spinal bones and muscles near the spine

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Since then, 17 additional medications have been approved by the FDA, but many have been withdrawn because of adverse effects, several are only approved for short-term (less than 12 weeks) use, and only 5 are currently available for long-term obesity therapy in the US

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These alterations can have an impact on signaling pathways related to lipid metabolism, inflammation, and insulin sensitivity, potentially improving disorders including hyperlipidemia and nonalcoholic fatty liver disease

UPDATE 6/25/2019: I cannot believe it has been over 7 years since I wrote this original article on MTHFR mutation treatment