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Archived from the original on February 27, 2021

p53, a classic tumor suppressor protein, responds to various cellular stress signals (e.g., DNA damage, oxidative stress) and influences cell fate through transcriptional regulation

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doi: 10.1016/j.freeradbiomed.2021.09.025 107 LeeGYHanSN

However, this random conjugation strategy leads to a heterogeneous distribution of drug-to-antibody ratios (DARs), typically ranging from 0 to 8, and the uncertainty of conjugation sites may affect antigen binding or pharmacokinetic stability