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t , Cumulative food intake

A randomized, double-blinded, placebo-controlled clinical trial involving 80 UC patients in remission was conducted from September 2009 to October 2010 [581]

These four protein complexes are the NADH:ubiquinone oxidoreductase complex (complex I of the respiratory chain), the succinate dehydrogenase complex (complex II of the respiratory chain), CDP-diacylglycerolinositol 3-phosphatidyltransferase (CDIPT), and solute carrier family 16 member 1 (SLC16A1)

10.1089/ars.2017.7123 15 DouZ.GhoshK.VizioliM

Hu H, Gan J

Postulated mechanisms of metformin action, including AMPK activation and complex I inhibition, have been demonstrated in the setting of a consistent pleiotropic activity of this drug, suggesting that several molecular targets could be involved (LaMoia and Shulman, 2021)
