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Timing considerations add complexity

The switch may cause transient weight fluctuation (1 to 3 pounds) during washout or titration, but this does not erase prior progress

They work by mimicking the actions of the GLP-1 hormone, which regulates appetite and food intake

Obesity is a multifactorial and complex chronic disease characterised by excess body weight and fat accumulation

Futile cycling of glucose has also been suggested to confer glucagons energy expenditure effects, whereby glucagon stimulates opposing pathways of hepatic glucose production and consumption (56)

Collectively they found that a truncated form of GLP-1 produced by gut cells was able to bind a G-protein coupled receptor (GPCR) expressed on pancreatic islet cells and in other tissues