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Current study also suggests that GSB-106 behaves as a partial BDNF-like agonist, since GSB-106 was found to intrinsically provide the cell survival (~ 26% increase over control) and is able to inhibit BDNF-mediated cell viability (by ~ 37%), when added competitively, thus exhibiting the profile of partial agonist

Network & Pathway Analysis Subgroup of Psychiatric Genomics, C

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doi: 10.1002/pmic.200900004

P., Shipman, T., Wang, Y
