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In addition, compared with the therapeutic value of a specific single strain, probiotic consortia containing Lactobacillus reuteri, Lactobacillus gasseri, Lactobacillus acidophilus, and Bifidobacterium lactis were demonstrated to better ameliorate DSS-induced colitis in the mouse model, with their mixed metabolites receiving slightly inferior benefits by comparison with the whole strain [99]

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Metabolites such as indoxyl sulfate and pcresol sulfate, when BBB integrity is compromised, can interacted with glial cells to promote oxidative stress, proinflammatory cascades, and mitochondrial dysfunction within the CNS

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Pain 2009, 9 (3), 173180

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10.1093/carcin/bgn179 Carcinogenesis 71 YangM.ParkJ

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