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FIGURE 3 The first choline-TMA lyase inhibitor, DMB, was identified by Wang and colleagues, which is shown to non-lethally inhibit distinct microbial TMA lyases, and reduce TMAO levels in mice fed a high-choline or L-carnitine diet (Wang et al., 2015)

Mechanistic reviews further describe periodontal LPS as a driver of FMO3 expression, intestinal barrier disruption, and systemic TMAO increases, providing a broader conceptual framework for the oralgut axis [25]

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[DOI] [PubMed] [Google Scholar] 30.Wachter S., Vogt M., Kreis R., Boesch C., Bigler P., Hoppeler H., Krahenbuhl S

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