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Description
Oral B12 has a bottleneck

Infection: A bacterial or viral infection of the shoulder joint

Not Accounting for Injection Volume A 1mL subcutaneous injection is already on the larger side
However, the convenience of a single morning dose means most researchers prefer once-daily administration, and the clinical data supporting split dosing specifically for AOD 9604 is limited

Endocrine Journal , 59(7), 529538

In rare cases you may suffer bruising, redness, swelling or itching at the injection site which is normally transient and limited to 48 hours