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Additionally, cell mediated- and humoral- immune response, and heat shock protein 70 expression were higher (p<0.05) in T1_HS and T2_HS
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Here this group reports a ruthenium-based nanocatalyst alleviating hypoxic TME, activating protein transient receptor potential melastatin 2 ion channel, promoting systemic immune response thereby eliciting its therapeutic efficacy against osteosarcoma.

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