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Premature puberty Pregnancy or suspicion of pregnancy Breast feeding Blood clotting disorders (HCG can potentially increase the risk of blood clots, which can be dangerous in these patients)

In KRAS-mutant cancer cells with or without LKB1 loss, increased expression of SSP genes and high serine synthesis allow the cells to tolerate serine starvation for survival (Kottakis et al., 2016

1 Mitochondria structure and function The adult human brain accounts for about 2% of total body weight but consumes approximately 20% of the bodys energy supply to sustain its high metabolic activity

13(1): doi: 10.1177/1557988318818280 9

Hydrogen peroxide (H 2 O 2 ) was purchased from Merck (Darmstadt, Germany)