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Notably, organs with high iron requirements and energy demands, such as the cardiovascular and nervous systems, are particularly affected [69, 70]

Interlaminar astrocytes connect to neurons, pia, and capillaries, suggesting roles such as cortical neuron communication, and may play an essential role in the BBB (Falcone et al., 2019)

Table 2 Summary of association studies between genetic polymorphisms on Glutathione-S-Transferases and outcomes in the cisplatin-based chemotherapy

doi: 10.1021/acsnano.8b01573 405 MarkmanJLRekechenetskiyAHollerELjubimovaJY

Michelet F, Gueguen R, Leroy P, Wellman M, Nicolas A, Siest G

Thyroid microenvironment has a high antioxidant metabolic profile at baseline due to inherently high intracellular ROS levels utilized for thyroid hormonogenesis