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Fumagillin and its synthetic analogue TNP-470 are both irreversible binders of the methionine aminopeptidase-2 (MetAP-2) and prevent the advancement of endothelial cell cycles and neovascularization [279, 306]

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Nanostructured lipid carriers: A promising carrier in targeted drug delivery system

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The animals were randomly distributed to receive saline (NaCl 0.9%0.1 mL/300 g of body weight) or HgCl 2 through intramuscular injection (first dose of 4.6 g/kg, subsequent doses of 0.07 g/kg/day) for 4 weeks, as shown in Figure 1