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Physiological limits to zinc bio-fortification of edible crops

Data availability All data generated or analyzed during this study are included in this published article

Shakya et al., 2018

Another comprehensive review found that glutathione synthesis becomes severely diminished in patients with uncontrolled diabetes, yet can be restored through dietary supplementation

The binding of VEGF-A to VEGFR 2 (predominantly found on EC of blood vessels) leads to angiogenesis, whereas VEGF-C and D preferentially bind to VEGFR-3, expressed predominantly on lymphatic EC, resulting in the proliferation of lymphatic vessels [23]

Variants S463D and S463K of EcGGT showed no detectable activities with considerable maturational defects (Hsu et al., 2009), while S463T mutant displayed 40% loss in activity without affecting autoprocessing, indicating that presence of hydroxyl group is required for autoprocessing and addition of charged residues at this position is detrimental for both processing and activity