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The S -nitrosylated COX-2 enzyme produces the lipid compound 15 R -hydroxyeicosatetraenoic acid (15 R -HETE) which is then converted via the action of 5-lipoxygenase (5-LOX) to the epimeric lipoxin, 15-epi-LXA 4

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The disclosures herein are intended to be considered separately, in combination, and in various subcombinations and permutations, without limitation, unless mutually incompatible