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Currently, it is not yet clear which of the selenoproteins are crucial for proper TG biosynthesis and whether their inadequate expression or function in the angio-follicular units of the thyroid gland may contribute to the development or perpetuation of autoimmune thyroid diseases or thyroid cancer [77]

Griffiths KK, Levy RJ

Patients present clinical symptoms such as lymphopenia, decreased ratios of T helper (Th) cells to cytotoxic T cells, decreased natural killer (NK) cell activity, and increased monocyte cytotoxicity

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Routing of glucose-6-phosphate toward the pentose phosphate pathway is of bilateral importance for cancer: through the oxidative phase, the pentose phosphate pathway will yield NADPH for fatty acid synthesis, cholesterol synthesis, and the detoxification of reactive oxygen species