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Description
As noted earlier, the active site has a high degree of hydrophobicity that allows binding of amino acids and cysteine S -conjugates with large noncharged side groups
These findings validate the therapeutic targeting of the system Xc pathway, although challenges related to tumor selectivity and potential systemic toxicity remain
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Physico-Chemical Properties
In conclusion, increasing ROS levels through GLN metabolism promotes ferroptosis by blocking GSH synthesis (Fig
Additionally, Paneth cells lacking Atg16L1 , Atg5 , or Atg7 showed impaired secretion of antimicrobial proteins, which confer intestinal protection against pathogens [105]
