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Bacterial persistence as a phenotypic switch
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Moreover, animal models (131) and tissue specimens obtained from patients with sarcoidosis (132) showed that hyperproduction of Th2 cytokines is accompanied by tissue macrophage activation and differentiation toward the M2 phenotype, which contributes to the development and maintenance of tissue foci of chronic inflammation, the formation of granulomas, and foci of fibrosis
Schroder, K., Hertzog, P
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