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Keshani M, Alikiaii B, Babaei Z, Askari G, Heidari Z, Sharma M, Bagherniya M (2024) The effects of L-carnitine supplementation on inflammation, oxidative stress, and clinical outcomes in critically ill patients with sepsis: a randomized, double-masked, controlled trial

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Less commonly, a polypeptide chain can form a beta-pleated sheet, in which hydrogen bonds form bridges between different regions of a single polypeptide that has folded back upon itself, or between two or more adjacent polypeptide chains

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Concurrently, RAGE hyperactivates oxidative stress via NF-B and p38-MAPK signaling, inducing ROS-mediated mitochondrial dysfunction, lipid peroxidation and DNA damage