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However, there have been no clinical trials that have evaluated and validated these compounds in SCA3 patients 31

Weakening of the endogenous antioxidant system leads to uncontrolled ROS production that outweighs the antioxidant capacity of the brain, causing developmental neurotoxicity
Additionally, the pathology is driven by dysregulated stress granule dynamics and impaired selective autophagic clearance of TDP-43 aggregates, particularly regarding persistent stress granules containing TDP-43 [337]

15 Mrtensson, J

H., Grande, C., & Moore, S

184,185 Upregulated USP20 expression in oxaliplatin-resistant HCC cells is associated with poor prognosis, while genetic knockdown or pharmacological inhibition of USP20 can trigger ferroptosis and increase the sensitivity of HCC cells to oxaliplatin both in vitro and in vivo
