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In coronary heart disease, accumulation of atherosclerotic plaque in the coronary arteries may prevent heart regions from getting adequate circulation, ultimately resulting in cardiac damage and impaired pumping ability

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FIGURE 3 The first choline-TMA lyase inhibitor, DMB, was identified by Wang and colleagues, which is shown to non-lethally inhibit distinct microbial TMA lyases, and reduce TMAO levels in mice fed a high-choline or L-carnitine diet (Wang et al., 2015)

doi: 10.1016/j.devcel.2020.06.008 [DOI] [PMC free article] [PubMed] [Google Scholar] 105