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[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Yoon H.-R., Hong Y.M., Boriack R.L., Bennett M.J

They hypothesized that topiramate has a complex mechanism of action that includes antagonism of several Glu receptors, blockade of voltage-dependent Na + channels, and inhibition of carbonic anhydrase (Ma et al., 2013)

Research Applications Mitochondrial -Oxidation Carnitine palmitoyltransferase I/II (CPT-I/II) activity, acylcarnitine shuttle, fatty acid flux Energy Metabolism Acetyl-CoA/CoA ratio modulation, glucose vs

The best time to take L-Carnitine varies based on personal goals, but options include before exercise, after exercise, in the morning while fasting, with meals, or before bedtime

Overall, these preclinical and clinical findings highlight mitochondria as a promising therapeutic target for depression, though larger, rigorously designed trials with well-stratified patient populations are needed to confirm efficacy and long-term safety
