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Taken together, these findings suggest a complex relationship among normal ROS flux, heightened ROS generation, and (patho)biological processes that can be regulated, in part, by GPx-1

Measurement of glyoxalase activities

The activation of major histocompatibility complex (MHC) Class II-dependent T-cells by citrullinated neoantigens promotes B-cells production of more ACPAs and the activation of inflammatory mediators like TNF-, IL-1, IL-6, and NF-B, leading to pannus formationa thickened synovial layer that invades and destroys cartilage and bone

Peptides are short chains of amino acids that act as building blocks of proteins such as collagen, elastin and keratin

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