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Description
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One small open-label study that provided 2530 g/kg/day (1500 g/day maximum) of methylcobalamin to 13 patients found no adverse effects ( N -acetyl-l-cysteine, one as a primary treatment and another as an add-on to risperidone
No additional indications have been approved beyond HIV-associated lipodystrophy, though ongoing research continues into NAFLD, cognitive function, and other metabolic applications
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An alternative strategy to target tyrosinase activity is to indirectly inhibit its phosphorylation and subsequent interaction with Tyrp1
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