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Its best to avoid it, especially if you are required to fast
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doi: 10.1152/ajpcell.00379.2020

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Endothelial dysfunction leads to impaired barrier integrity and triggers the production of proinflammatory cytokines, chemokines, and ROS, along with the recruitment, adherence, and subendothelial migration of proinflammatory leukocytes, resulting in atherosclerotic lesions
This possibility is supported by recent reports that ketamine-induction of antidepressant behavioral responses are blocked in BDNF null mice 164,165