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Verdict: Limited evidence there are plausible gut-related mechanisms and some encouraging animal findings, but published human outcome data is too sparse and too poorly reported to confirm real clinical benefits [6][1113]

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doi: 10.1111/j.1743-6109.2006.00116.x

As they stated, 'The agar plaque technique has the obvious advantage that it permits the recognition and enumeration of individual antibody-forming cells even in situations where only a few such cells are present among millions of cells that do not release this antibody' (Jerne, Nordin, Henry, 1965)

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