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Etiological Factors in Parkinson's Disease Parkinson's disease is a multifactorial neurodegenerative disorder arising from a complex interplay of genetic predispositions, environmental influences, aging, and dietary factors (Figure 3)

When both the hypothalamus and pituitary receive stimulatory signals, the resulting testosterone production more closely mimics natural circadian rhythms, with appropriate morning peaks and afternoon declines rather than the flat levels often seen with testosterone replacement

Subsequent clinical cases revealed that -synuclein pathology is not only restricted to the soma but also extends to neurites which led to the coinage of the term Lewy neurites ( Under normal physiological conditions -synuclein exists mostly in an N acetylated membrane bound form which results in adoption of an -helical structure (Runfola et al., 2020)

2 Unlike other types of cell death, such as apoptosis, necrosis, and autophagy, ferroptosis is an iron-dependent form of regulated cell death characterized by impaired mitochondrial morphology, iron overload, disturbed lipid peroxidation, and excessive oxidative stress

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Increased intake of Omega-3 fatty acids has been evident in reducing neuroinflammation and slower neurodegeneration in PD patients (148)