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At low levels, ROS induce nuclear factor of activated T cells (NFAT), which supports metabolic changes by regulating the transcription of hypoxia-inducible factor-1 alpha (HIF-1) [139]

Patients experienced substantial pain and symptom improvements within three weeks of being on a calorie restrictive diet

3), leading to its selection for subsequent mechanistic studies

Mitochondrial dysfunction as a mechanism of drug-induced hepatotoxicity: current understanding and future perspectives

A schematic diagram showing the most well characterized epigenetic modifications are shown in Figure 1