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In the past, most studies focused on the diverse roles of apoptosis, pyroptosis, autophagy, and necrosis in diseases

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doi: 10.1016/0022-4731(84)90208-5 253 BenedekGZhangJNguyenHKentGSeifertHADavinSet al

However, factors such as cigarette smoking, subclinical infections, environmental pollutants, occupational exposures, chronic microaspiration of gastric content, abnormal lung microbiota composition, and genetic predisposition may cause repeated AEC injury ( Complex bidirectional interactions between epithelial cells, mesenchymal cells, and ECM subsequently induce a series of cellular events, including fibroblasts differentiation into myofibroblasts, migration, proliferation, and activation of AECs and fibroblasts, inhibition of apoptosis, and persistent abnormal ECM secretion