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3.5 Dysregulated collagen metabolism In parallel to various signaling cascades, dysregulation in collagen metabolism and homeostasis also contributes to OSFs pathogenesis (Cabral-Pacheco et al., 2020), and LOX activity, which is responsible for the intra- and inter-molecular cross-linking of non-degradable (proteolytic degradation) collagen fibrils ( OSF histological progression can be categorized into four stages based on collagen formation and accumulation, which include (i) very early, (ii) early, (iii) moderately advanced, and (iv) advanced

1B) 29,33-36 to achieve stable performance of 805% correct over 3 consecutive days (20 trials

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