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The most significant weight loss usually occurs between the 5mg and 15mg dose levels, typically months two through six of treatment

Cellular Senescence and Aging Cellular senescence is a state of permanent cell cycle arrest accompanied by characteristic changes in gene expression, secretion of inflammatory factors known as the senescence-associated secretory phenotype (SASP), and resistance to apoptosis

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10.3389/fimmu.2017.01873 12 BourasE