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To validate our main results, we also considered the largest GWAS of AD that does not contain proxy cases: the International Genomics of Alzheimers Project (IGAP) consortium GWAS of late-onset AD 44

Impaired regulation of the incretin effect in patients with type 2 diabetes

Consistent with our results, some studies have reported a negative correlation between OBS and inflammatory biomarkers

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Cocaine addiction In a small crossover study ( n = 13), designed to determine tolerability and safety, participants (currently abstaining from cocaine use) were given 2400 mg of NAC or placebo over 2 days.34 Four days later, participants were crossed over to the alternative arm