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Other metals which are present in the environment as industrial pollutants are not able to generate free radicals by shuttling between contiguous oxidation states but it is known that organisms exposed either in their natural environment or in toxicological experiments show signs of oxidative stress, and some metals, such as As, Cd and Hg, are also carcinogenic to humans

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Mitochondrial matrix H 2 O 2 levels were evaluated with the genetically encoded mitochondrial localized oxidant sensor HyPer7 19 and found to be significantly increased in both PRX3 KO clones (Fig