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The BV-2 cell line, representing microglia, serves as a well-established in vitro model for studying microglia-induced neuroinflammation 43

Among the investigated compounds in the study, two compounds 3a and 3b, congeners (carbonyl reduction) of the pyridyl azachalcones were found to be potent enzyme inhibitors than kojic acid (IC 50 = 27.30 M) (Figure 5(a), 3a 3b )

The pathogenesis of microthrombi in COVID-19 cannot be controlled by DOAC: NETosis should be the target

doi:10.1016/j.jmb.2008.06.083

We show that inositol-requiring enzyme 1 (IRE1), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis