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Effect of dopamine agonists and antagonists on neurotensin-induced antinociception

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The PepT1 (SLC15A1) transporter a proton-coupled oligopeptide transporter normally expressed in the small intestine is dramatically upregulated in the colon during inflammatory bowel disease

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While very high oral doses (1,000 to 2,000 mcg) can achieve some passive absorption without intrinsic factor roughly 1% of the dose is absorbed passively many clinicians prefer the reliability and rapid correction offered by injections in this population