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Due to its methylation by a catecholamine O-methyl transferase (COMT), levodopa is administered in conjunction with COMT inhibitors such as entacapone, tolcapone, and benzaseride [9]

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doi: 10.3389/fnins.2023.1081347 296 ZhouJ.HuangW

Finally, pluripotency factor such as ZFP281 has been observed to orchestrate early metastatic dormancy by enabling dissemination through EMT and concurrently imposes long-term quiescence in distant sites, describing non-traditional metastasis (165)

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