inhibitors of glutathione peroxidase peroxidase-1 and neuromodulation: Novel potentials an old enzyme GPX4-independent ferroptosis—a new strategy in

35 , 212226.e214 (2023)

Despite their potential, polyphenols remain underutilized in functional foods and dietary supplements due to several physicochemical properties, including low epithelial permeability, poor solubility in gastrointestinal fluids, structural modifications during digestion, and limited oral bio-accessibility (128, 129)

Steward, O

confirmed these findings in human samples and further demonstrated a positive correlation between anti-satellite IgG levels and pain intensity in FMS

Mechanistically, PI-driven ChaC1 induction largely depended on ATF4, as CRISPR/Cas9-mediated ATF4 knockout abrogated this response (Fig

& Yamauchi, Y