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The activation of IGF-1R triggers multiple signal cascades in a cell context dependent manner to regulate multiple cellular functions from proliferation and survival to differentiation into specific cell lineages[39]

doi: 10.1186/s12931-024-02855-6 46 KrumdieckCLdos SantosJEHoKJ

This review thoroughly shows the cellular and molecular signaling mechanisms that curcumin utilizes to provide neuroprotective effects in NDs

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S3AF) showed that the inhibition of GSK3 activity also impairs the association between STARD3 and VAP-B

The master chondrogenic transcription factor Sox9 on the one hand promotes glutamine utilization and on the other hand suppresses fatty acid oxidation, thus orchestrating major metabolic rewiring necessary for chondrogenesis