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Although D 4 R does not undergo desensitization alone, it can undergo desensitization when co-expressed with a G1 and arrestin3 fusion protein (G1*arrestin3) [27, 36]

gRNAs with specific overhangs were annealed into a BsmBI-digested plentiCRISPRv2 plasmid (Addgene #52961, gift from Feng Zhang) 57

Preservatives or specific vitamins in the iv fluids are the most common triggers

Several studies have explored GSL accumulation in cruciferous plants 7,13,57

doi: 10.1016/0197-4580(90)90110-l

This breakdown often results from complex interactions between environmental factors, smoking, and genetic predispositions, triggering the production of autoantibodies against citrullinated antigensa hallmark of RA ( Figure 2 ) (47, 48)