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The anti-inflammatory effect prevents the chronic low-grade inflammation that keeps injured soft tissue in a partial-repair state, cycling between managed pain and flare rather than progressing toward structural restoration

A randomized control trial of cannula versus 27G hypodermic subcision (50 patients per group) revealed four cases of infection in the needle group, compared to 0 in the subcision group [13]

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Pharmacovigilance data from FAERS ( 10.3389/fimmu.2023.1127128 ) similarly demonstrated a strong hypertension signal for VEGF inhibitors and for ICI+ VEGFi combinations, whereas ICIs alone showed no hypertension signal (IC025 1.456

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