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One of the nuclear receptors, REV-ERB, is also a negative regulator of the rhythmic CLOCK transcription circuit

Based off my experience, and my experience alone, I can say it works (as long as you also work of course)

Symptoms of B12 deficiency include: Fatigue Low mood or personality/mood changes Irritability Lethargy Headaches Palpitations Loss of appetite Pale yellow tint to the skin A feeling of pins and needles (paraesthesia) Poor memory Impaired cognitive performance Depression Weakness Impaired digestion Inflammation Gastrointestinal lesions Neurological damage Since B12 is primarily found in animal products, any change in ones diet that leads to a decrease in the consumption of such products such as a vegan , vegetarian, or low-fat diet can increase the chance of a person developing a B12 deficiency

PMC 5933935

Novel role for glutathione S-transferase pi

Eggs: 50% You may have noticed that eggs didnt make it on the list of B12 foods above